Note the significant glomerulosclerosis and proteinaceous casts. From left to right, micrographs are representative PAS-stained sections from: WT, dox-treated podocin rtTA, and dox-treated podocin rtTa/NICD mice harvested at day 10 post induction. It features Pincer as he and the Mosquito Brothers Neato, Veeto, and Sweetheart Mosquito trick protagonist Bug into becoming a Starship Ranger so he can lure in humans for them to eat. ( b) Tet-o-NICD1 mice were crossed with podocin rtTA animals for podocyte-specific expression of Notch1 (podocin rtTA/NICD1, schematic far left panel). 'Kick It Up a Notch' is a song from the Starkid musical comedy show Starship. Note the significant tubulointerstitial fibrosis in double-transgenic mice after dox treatment. From left to right micrographs are representative of periodic acid–Schiff (PAS)-stained sections from: wild type (WT), Pax8rtTA with dox, and Pax8rtTA/NICD with dox-fed mice harvested at day 28 post induction. Donatello points frantically at the top of the containment chamber, which has begun wobbling dangerously. From up so high, Donatello can’t read his expression, but it’s probably something like resigned disappointment or resigned exasperation or maybe, if he’s lucky, concern. Upon doxycycline (dox) administration animals express the Notch intracellular domain in tubule epithelial cells. The Baron turns up at the sound of Donatello’s voice. Animals were crossed with tetracycline-inducible (tet-o) NICD1 mice (Pax8rtTA/NICD1, schematic far left panel). ( a) Pax8rtTA animals express the reverse tetracycline transactivator under the Pax8 (tubule epithelial cell specific) promoter. Sustained expression of the Notch1 intracellular domain is sufficient to cause tubulointerstitial fibrosis and glomerulosclerosis.
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